Olivopontocerebellar Atrophy Essay -- Health Medicine Medical Essays

Olivopontocerebellar AtrophyAbstract Olivopontocerebellar Atrophy(OPCA), is characterized by neuronal corruption of the cerebellar cortex, the inferior olive, and the pons. The symptoms associated with it are primarily cerebellar ataxia with disturbances in equilibrium and gait. However, broader symptomology is usually seen with OPCA. Current research is focusing on iii primary systems thought to be responsible for the etiology of OPCA. They are excitative amino acid disturbances, oligodendroglial microtubular tangles, and phospholipid metabolism disorders. The only treatment for OPCA is therapy focusing on improving the dysphagia associated with the disorder. Olivopontocerebellar Atrophy Olivopontocerebellar Atrophy (OPCA) is a disease characterized primarily by the retrogression of neurons in the cerebellar cortex, pons, and inferior olive. It is a genetic disease, cosmos either autosomal dominant or autosomal recessive in nature. This disorder, which usually occurs in the mid dle years of life, presents symptoms of cerebellar ataxia, equilibrium disturbance, nystagmus, dysphasia, dysarthria, and perchance intellectual deficits. According to Merritt, the pathology of OPCA includes loss of Purkinje cells, reduction of the number of neurons in the molecular(a) and granular layers of the cerebellum, degeneration of the folia and white matter of the cerebellum, shrink of the inferior olives and of the olivo-cerebellar connections, and wasting of the pontine nuclei, arcuate nuclei, and brachium pontis (15). In addition to this, degeneration of the spinocerebellar tracts, corticospinal tracts, and frontal and temporal lobes has been describe (15). Biopsies on living OPCA patients have suggested that there are n... ...cerebellar atrophy. memorial of Neurology, 26362-367, 1989. 12. Kish, S., Robitaille, Y., El-Awar, M. et. al. Brain amino acid reductions in one family with chromosome 6p-linked dominantly inherited olivopontocerebellar atrophy. account of Neurology, 30780-784, 1991. 13.Landis, D., Rosenburg, R., Landis, S. et. al. Olivopontocerebellar degeneration. Archives of Neurology, 31295--307, 1974. 14. Makowiec, R., Albin, R., Cha, J-H. et. al. Two types of quisqualate receptors are decreased in human olivopontocerebellar atrophy cerebellar cortex. Brain Research, 523309-312, 1990. 15. Merritt, Houston. A Textbook of Neurology. ley and Febiger, Philadelphia. 1967 16. Nakazato, Y., Yamazaki, H., Hirato, J. et. al. Oligodendroglial microtubular tangles in olivopontocerebellar atrophy. Journal of Neuropathology and Experimental Neurology, 49521-530, 1990. Olivopontocerebellar Atrophy Essay -- health Medicine Medical EssaysOlivopontocerebellar AtrophyAbstract Olivopontocerebellar Atrophy(OPCA), is characterized by neuronal degeneration of the cerebellar cortex, the inferior olive, and the pons. The symptoms associated with it are primarily cerebellar ataxia with disturbances in equilibrium and gait. However, bro ader symptomology is usually seen with OPCA. Current research is focusing on triple primary systems thought to be responsible for the etiology of OPCA. They are excitant amino acid disturbances, oligodendroglial microtubular tangles, and phospholipid metabolism disorders. The only treatment for OPCA is therapy focusing on improving the dysphagia associated with the disorder. Olivopontocerebellar Atrophy Olivopontocerebellar Atrophy (OPCA) is a disease characterized primarily by the degeneration of neurons in the cerebellar cortex, pons, and inferior olive. It is a genetic disease, beingness either autosomal dominant or autosomal recessive in nature. This disorder, which usually occurs in the middle years of life, presents symptoms of cerebellar ataxia, equilibrium disturbance, nystagmus, dysphasia, dysarthria, and perchance intellectual deficits. According to Merritt, the pathology of OPCA includes loss of Purkinje cells, reduction of the number of neurons in the molecular and g ranular layers of the cerebellum, degeneration of the folia and white matter of the cerebellum, atrophy of the inferior olives and of the olivo-cerebellar connections, and atrophy of the pontine nuclei, arcuate nuclei, and brachium pontis (15). In addition to this, degeneration of the spinocerebellar tracts, corticospinal tracts, and frontal and temporal lobes has been account (15). Biopsies on living OPCA patients have suggested that there are n... ...cerebellar atrophy. Annals of Neurology, 26362-367, 1989. 12. Kish, S., Robitaille, Y., El-Awar, M. et. al. Brain amino acid reductions in one family with chromosome 6p-linked dominantly inherited olivopontocerebellar atrophy. Annals of Neurology, 30780-784, 1991. 13.Landis, D., Rosenburg, R., Landis, S. et. al. Olivopontocerebellar degeneration. Archives of Neurology, 31295--307, 1974. 14. Makowiec, R., Albin, R., Cha, J-H. et. al. Two types of quisqualate receptors are decreased in human olivopontocerebellar atrophy cerebellar cor tex. Brain Research, 523309-312, 1990. 15. Merritt, Houston. A Textbook of Neurology. grass and Febiger, Philadelphia. 1967 16. Nakazato, Y., Yamazaki, H., Hirato, J. et. al. Oligodendroglial microtubular tangles in olivopontocerebellar atrophy. Journal of Neuropathology and Experimental Neurology, 49521-530, 1990.